Lymph node metastases develop through a wider evolutionary bottleneck than distant metastases

Genetic diversity among metastases is poorly understood but contains important information about disease evolution at secondary sites. Here we investigate inter- and intra-lesion heterogeneity for two types of metastases that associate with different clinical outcomes: lymph node and distant organ m...

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Veröffentlicht in:Nat Genet
Hauptverfasser: Reiter, Johannes G., Hung, Wei-Ting, Lee, I-Hsiu, Nagpal, Shriya, Giunta, Peter, Degner, Sebastian, Liu, Gang, Wassenaar, Emma C.E., Jeck, William R., Taylor, Martin S., Farahani, Alexander A., Marble, Hetal D., Knott, Simon, Kranenburg, Onno, Lennerz, Jochen K., Naxerova, Kamila
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7343611/
https://ncbi.nlm.nih.gov/pubmed/32451459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-0633-2
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