Lifelong SIRT-1 overexpression attenuates large artery stiffening with advancing age

Advanced age is accompanied by aortic stiffening that is associated with decreased vascular expression of sirtuin-1 (SIRT-1). Interventions that increase SIRT-1 expression also lower age-related aortic stiffness. Therefore, we sought to determine if lifelong SIRT-1 overexpression would attenuate age...

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Bibliografiske detaljer
Udgivet i:Aging (Albany NY)
Main Authors: Machin, Daniel R., Auduong, Yauling, Gogulamudi, Venkateswara R., Liu, Yu, Islam, Md. Torikul, Lesniewski, Lisa A., Donato, Anthony J.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals 2020
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7343505/
https://ncbi.nlm.nih.gov/pubmed/32564006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103322
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