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Placenta-specific 8 limits IFNγ production by CD4 T cells in vitro and promotes establishment of influenza-specific CD8 T cells in vivo

During type 1 immune responses, CD4 T helper 1 (Th1) cells and CD8 T cells are activated via IL-12 and contribute to the elimination of intracellular pathogens through interferon gamma (IFNγ) production. In this study, we identified Placenta-specific 8 (Plac8) as a gene that is uniquely expressed in...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: Slade, Chris D., Reagin, Katie L., Lakshmanan, Hari G., Klonowski, Kimberly D., Watford, Wendy T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7343148/
https://ncbi.nlm.nih.gov/pubmed/32639988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0235706
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