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Chloroquine Combined with Imatinib Overcomes Imatinib Resistance in Gastrointestinal Stromal Tumors by Inhibiting Autophagy via the MAPK/ERK Pathway

BACKGROUND: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. However, up to 40–50% of GISTs develop secondary resistance after an average of 24 months of imatinib treatment. It has been reported that autophagy can promote the survival o...

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Bibliografiske detaljer
Udgivet i:Onco Targets Ther
Main Authors: Zheng, Song, Shu, Yefei, Lu, Yidan, Sun, Yangcheng
Format: Artigo
Sprog:Inglês
Udgivet: Dove 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7342409/
https://ncbi.nlm.nih.gov/pubmed/32753885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S256935
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