The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules

The Salmonella enterica effector SteD depletes mature MHC class II (mMHCII) molecules from the surface of infected antigen-presenting cells through ubiquitination of the cytoplasmic tail of the mMHCII β chain. Here, through a genome-wide mutant screen of human antigen-presenting cells, we show that...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Cell Host Microbe
Autors principals: Alix, Eric, Godlee, Camilla, Cerny, Ondrej, Blundell, Samkeliso, Tocci, Romina, Matthews, Sophie, Liu, Mei, Pruneda, Jonathan N., Swatek, Kirby N., Komander, David, Sleap, Tabitha, Holden, David W.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7342019/
https://ncbi.nlm.nih.gov/pubmed/32526160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2020.04.024
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars