Cell Type Impacts Accessibility of mRNA to Silencing by RNA Interference

RNA interference (RNAi) is a potent mechanism that silences mRNA and protein expression in all cells and tissue types. RNAi is known to exert many of its functional effects in the cytoplasm, and thus, the cellular localization of target mRNA may impact observed potency. Here, we demonstrate that cel...

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Bibliografiske detaljer
Udgivet i:Mol Ther Nucleic Acids
Main Authors: Ferguson, Chantal M., Echeverria, Dimas, Hassler, Matthew, Ly, Socheata, Khvorova, Anastasia
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7340969/
https://ncbi.nlm.nih.gov/pubmed/32650236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.06.006
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