Targeted sequencing of genes associated with the mismatch repair pathway in patients with endometrial cancer

Germline variants inactivating the mismatch repair (MMR) genes MLH1, MSH2, MSH6 and PMS2 cause Lynch syndrome that implies an increased cancer risk, where colon and endometrial cancer are the most frequent. Identification of these pathogenic variants is important to identify endometrial cancer patie...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Singh, Ashish Kumar, Talseth-Palmer, Bente, McPhillips, Mary, Lavik, Liss Anne Solberg, Xavier, Alexandre, Drabløs, Finn, Sjursen, Wenche
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2020
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7340288/
https://ncbi.nlm.nih.gov/pubmed/32634176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0235613
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