Crystal structure and interaction studies of human DHTKD1 provide insight into a mitochondrial megacomplex in lysine catabolism

DHTKD1 is a lesser-studied E1 enzyme among the family of 2-oxoacid de­hydrogenases. In complex with E2 (di­hydro­lipo­amide succinyltransferase, DLST) and E3 (dihydrolipo­amide de­hydrogenase, DLD) components, DHTKD1 is involved in lysine and tryptophan catabolism by catalysing the oxidative de­carb...

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Detalhes bibliográficos
Publicado no:IUCrJ
Main Authors: Bezerra, Gustavo A., Foster, William R., Bailey, Henry J., Hicks, Kevin G., Sauer, Sven W., Dimitrov, Bianca, McCorvie, Thomas J., Okun, Jürgen G., Rutter, Jared, Kölker, Stefan, Yue, Wyatt W.
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2020
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7340257/
https://ncbi.nlm.nih.gov/pubmed/32695416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S205225252000696X
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