Oral epithelial IL-22/STAT3 signaling licenses IL-17-mediated immunity to oral mucosal candidiasis

Oropharyngeal candidiasis (OPC, thrush) is an opportunistic infection caused by the commensal fungus Candida albicans. IL-17 and IL-22 are cytokines produced by Type 17 lymphocytes. Both cytokines mediate antifungal immunity yet activate quite distinct downstream signaling pathways. While much is no...

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Vydáno v:Sci Immunol
Hlavní autoři: Aggor, Felix E.Y., Break, Timothy J., Trevejo-Nuñez, Giraldina, Whibley, Natasha, Coleman, Bianca M., Bailey, Rachel D., Kaplan, Daniel H., Naglik, Julian R., Shan, Wei, Shetty, Amol C., McCracken, Carrie, Durum, Scott K., Biswas, Partha S., Bruno, Vincent M., Kolls, Jay K., Lionakis, Michail S., Gaffen, Sarah L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7340112/
https://ncbi.nlm.nih.gov/pubmed/32503875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aba0570
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