Vulnerability of drug‐resistant EML4‐ALK rearranged lung cancer to transcriptional inhibition

A subset of lung adenocarcinomas is driven by the EML4‐ALK translocation. Even though ALK inhibitors in the clinic lead to excellent initial responses, acquired resistance to these inhibitors due to on‐target mutations or parallel pathway alterations is a major clinical challenge. Exploring these me...

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Udgivet i:EMBO Mol Med
Main Authors: Paliouras, Athanasios R, Buzzetti, Marta, Shi, Lei, Donaldson, Ian J, Magee, Peter, Sahoo, Sudhakar, Leong, Hui‐Sun, Fassan, Matteo, Carter, Matthew, Di Leva, Gianpiero, Krebs, Matthew G, Blackhall, Fiona, Lovly, Christine M, Garofalo, Michela
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7338803/
https://ncbi.nlm.nih.gov/pubmed/32558295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201911099
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