Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia

The immune system of patients infected by SARS-CoV-2 is severely impaired. Detailed investigation of T cells and cytokine production in patients affected by COVID-19 pneumonia are urgently required. Here we show that, compared with healthy controls, COVID-19 patients’ T cell compartment displays sev...

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Publicado no:Nat Commun
Main Authors: De Biasi, Sara, Meschiari, Marianna, Gibellini, Lara, Bellinazzi, Caterina, Borella, Rebecca, Fidanza, Lucia, Gozzi, Licia, Iannone, Anna, Lo Tartaro, Domenico, Mattioli, Marco, Paolini, Annamaria, Menozzi, Marianna, Milić, Jovana, Franceschi, Giacomo, Fantini, Riccardo, Tonelli, Roberto, Sita, Marco, Sarti, Mario, Trenti, Tommaso, Brugioni, Lucio, Cicchetti, Luca, Facchinetti, Fabio, Pietrangelo, Antonello, Clini, Enrico, Girardis, Massimo, Guaraldi, Giovanni, Mussini, Cristina, Cossarizza, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7338513/
https://ncbi.nlm.nih.gov/pubmed/32632085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17292-4
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