Neuronal activity disrupts myelinated axon integrity in the absence of NKCC1b

Through a genetic screen in zebrafish, we identified a mutant with disruption to myelin in both the CNS and PNS caused by a mutation in a previously uncharacterized gene, slc12a2b, predicted to encode a Na(+), K(+), and Cl(−) (NKCC) cotransporter, NKCC1b. slc12a2b/NKCC1b mutants exhibited a severe a...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Marshall-Phelps, Katy L.H., Kegel, Linde, Baraban, Marion, Ruhwedel, Torben, Almeida, Rafael G., Rubio-Brotons, Maria, Klingseisen, Anna, Benito-Kwiecinski, Silvia K., Early, Jason J., Bin, Jenea M., Suminaite, Daumante, Livesey, Matthew R., Möbius, Wiebke, Poole, Richard J., Lyons, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337504/
https://ncbi.nlm.nih.gov/pubmed/32364583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201909022
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