Hirudin Ameliorates Renal Interstitial Fibrosis via Regulating TGF-β1/Smad and NF-κB Signaling in UUO Rat Model

PURPOSE: Hirudin, a polypeptide structure containing 65 amino acids, is a potent natural thrombin inhibitor with anticoagulant property extracted from Hirudo medicinalis. It has been reported to have anti-inflammatory and antifibrotic property. Here we explored the renoprotective effect of hirudin o...

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Veröffentlicht in:Evid Based Complement Alternat Med
Hauptverfasser: Yang, Kang, Fan, Boya, Zhao, Qingyun, Ji, Yue, Liu, Panying, Gao, Shan, Ren, Tong, Dou, Yitian, Pei, Ming, Yang, Hongtao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7336220/
https://ncbi.nlm.nih.gov/pubmed/32714415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/7291075
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