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ATP hydrolysis by the SNF2 domain of Dnmt5 is coupled to both specific recognition and modification of hemimethylated DNA
C. neoformans Dnmt5 is an unusually specific maintenance-type CpG methyltransferase (DNMT) that mediates long-term epigenome evolution. It harbors a DNMT domain and SNF2 ATPase domain. We find that the SNF2 domain couples substrate specificity to an ATPase step essential for DNA methylation. Couplin...
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| 發表在: | Mol Cell |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7335330/ https://ncbi.nlm.nih.gov/pubmed/32437639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.04.029 |
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