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Polymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation
The spatial organization of chromosomes has key functional roles, yet how chromosomes fold remains poorly understood at the single-molecule level. Here, we employ models of polymer physics to investigate DNA loci in human HCT116 and IMR90 wild-type and cohesin depleted cells. Model predictions on si...
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| Опубликовано в: : | Nat Commun |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7335158/ https://ncbi.nlm.nih.gov/pubmed/32620890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17141-4 |
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