Telomere shortening produces an inflammatory environment that increases tumor incidence in zebrafish

Cancer incidence increases exponentially with age when human telomeres are shorter. Similarly, telomerase reverse transcriptase (tert) mutant zebrafish have premature short telomeres and anticipate cancer incidence to younger ages. However, because short telomeres constitute a road block to cell pro...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Lex, Kirsten, Maia Gil, Mariana, Lopes-Bastos, Bruno, Figueira, Margarida, Marzullo, Marta, Giannetti, Kety, Carvalho, Tânia, Ferreira, Miguel Godinho
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2020
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7334448/
https://ncbi.nlm.nih.gov/pubmed/32554492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1920049117
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