Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes

RATIONALE: Impaired myocardial relaxation is an intractable feature of several heart failure (HF) etiologies. In human HF, detyrosinated microtubules stiffen cardiomyocytes and impair relaxation. Yet the identity of detyrosinating enzymes have remained ambiguous, hindering mechanistic study and ther...

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Publicat a:Circ Res
Autors principals: Chen, Christina Yingxian, Salomon, Alexander K., Caporizzo, Matthew A., Curry, Sam, Kelly, Neil A., Bedi, Kenneth, Bogush, Alexey I., Krämer, Elisabeth, Schlossarek, Saskia, Janiak, Philip, Moutin, Marie-Jo, Carrier, Lucie, Margulies, Kenneth B., Prosser, Benjamin L.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7334093/
https://ncbi.nlm.nih.gov/pubmed/32272864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.119.315947
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