Gain-of-function genetic alterations of G9a drive oncogenesis

Epigenetic regulators, when genomically altered, may become driver oncogenes that mediate otherwise unexplained pro-oncogenic changes lacking a clear genetic stimulus, such as activation of the WNT/β-catenin pathway in melanoma. This study identifies previously unrecognized recurrent activating muta...

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Publicat a:Cancer Discov
Autors principals: Kato, Shinichiro, Weng, Qing Yu, Insco, Megan L, Chen, Kevin Y, Muralidhar, Sathya, Poźniak, Joanna, Diaz, Joey Mark S, Drier, Yotam, Nguyen, Nhu, Lo, Jennifer A, van Rooijen, Ellen, Kemeny, Lajos V, Zhan, Yao, Feng, Yang, Silkworth, Whitney, Powell, C Thomas, Liau, Brian B, Xiong, Yan, Jin, Jian, Newton-Bishop, Julia, Zon, Leonard I, Bernstein, Bradley E, Fisher, David E
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7334057/
https://ncbi.nlm.nih.gov/pubmed/32269030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0532
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