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Identification and Quantification of Novel Major Metabolites of the Steroidal Aromatase Inhibitor, Exemestane
Exemestane (EXE) is an aromatase inhibitor used for the prevention and treatment of estrogen receptor–positive breast cancer. Although the known major metabolic pathway for EXE is reduction to form the active 17β-dihydro-EXE (17β-DHE) and subsequent glucuronidation to 17β-hydroxy-EXE-17-O-β-D-glucur...
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| Wydane w: | Drug Metab Dispos |
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| Główni autorzy: | , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
The American Society for Pharmacology and Experimental Therapeutics
2018
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7333658/ https://ncbi.nlm.nih.gov/pubmed/30257855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.118.081166 |
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