Neurorestorative Effects of a Novel Fas-Associated Factor 1 Inhibitor in the MPTP Model: An [(18)F]FE-PE2I Positron Emission Tomography Analysis Study

Fas-associated factor 1 (FAF1), a Fas-binding protein, is implicated in neuronal cell death in Parkinson’s disease (PD). We examined the effects of a novel FAF1 inhibitor, KM-819, in dopaminergic neurons in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model using [(18)F]FE-PE2I positr...

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Publicat a:Front Pharmacol
Autors principals: Park, Hyun Soo, Song, Yoo Sung, Moon, Byung Seok, Yoo, Sung-Eun, Lee, Jae Moon, Chung, Yeon-Tae, Kim, Eunhee, Lee, Byung Chul, Kim, Sang Eun
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7333457/
https://ncbi.nlm.nih.gov/pubmed/32676027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00953
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