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Optochemical Control of Protein Localization and Activity Within Cell-Like Compartments

We report inducible dimerization strategies to control protein positioning, enzymatic activity, and organelle assembly inside synthetic cell-like compartments upon photostimulation. Using a photocaged TMP-Haloligand compound, we demonstrate small molecule and light-induced dimerization of DHFR and H...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Caldwell, Reese M., Bermudez, Jessica G., Thai, David, Aonbangkhen, Chanat, Schuster, Benjamin S., Courtney, Taylor, Deiters, Alexander, Hammer, Daniel A., Chenoweth, David M., Good, Matthew C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7330991/
https://ncbi.nlm.nih.gov/pubmed/29671583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00131
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