Decreased Neuronal Excitability in Medial Prefrontal Cortex during Morphine Withdrawal is associated with enhanced SK channel activity and upregulation of small GTPase Rac1

Rationale: Neuroadaptations in the medial prefrontal cortex (mPFC) and Nucleus Accumbens (NAc) play a role in the disruption of control-reward circuits in opioid addiction. Small Conductance Calcium-Activated Potassium (SK) channels in the mPFC have been implicated in neuronal excitability changes d...

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Опубликовано в: :Theranostics
Главные авторы: Qu, Liang, Wang, Yuan, Li, Yang, Wang, Xin, Li, Nan, Ge, Shunnan, Wang, Jing, Wang, Gene-Jack, Volkow, Nora D., Lang, Bing, Wang, Ping, Wu, Hao, Zeng, Jie, Fu, Jian, Li, Jiaming, Zhang, Yue, Wang, Xuelian
Формат: Artigo
Язык:Inglês
Опубликовано: Ivyspring International Publisher 2020
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7330845/
https://ncbi.nlm.nih.gov/pubmed/32641997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.44893
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