Efficient CRISPR-Cas9-Mediated Gene Ablation in Human Keratinocytes to Recapitulate Genodermatoses: Modeling of Netherton Syndrome

Current efforts to find specific genodermatoses treatments and define precise pathogenesis mechanisms require appropriate surrogate models with human cells. Although transgenic and gene knockout mouse models for several of these disorders exist, they often fail to faithfully replicate the clinical a...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Gálvez, Victoria, Chacón-Solano, Esteban, Bonafont, Jose, Mencía, Ángeles, Di, Wei-Li, Murillas, Rodolfo, Llames, Sara, Vicente, Asunción, Del Rio, Marcela, Carretero, Marta, Larcher, Fernando
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7329935/
https://ncbi.nlm.nih.gov/pubmed/32637457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.05.031
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