Reduction of the serotonin 5-HT(1B) and 5-HT(2A) receptor-mediated contraction of human pulmonary artery by the combined 5-HT(1B) receptor antagonist and serotonin transporter inhibitor LY393558

BACKGROUND: LY393558 is a combined antagonist of serotonin (5-HT) 5-HT(1B) receptors and inhibitor of serotonin transporter (SERT). LY393558 reduces 5-HT-induced vasoconstriction and remodelling of rat and/or mouse pulmonary arteries. The aim of our study was to examine the effect of LY393558 on the...

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Detalhes bibliográficos
Publicado no:Pharmacol Rep
Main Authors: Baranowska-Kuczko, Marta, Kozłowska, Hanna, Schlicker, Eberhard, Göthert, Manfred, MacLean, Margaret R., Kozłowski, Mirosław, Kloza, Monika, Sadowska, Olga, Malinowska, Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2020
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7329800/
https://ncbi.nlm.nih.gov/pubmed/32333296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s43440-020-00105-2
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