The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in multiple myeloma

Proteasome inhibitors have provided a significant advance in the treatment of multiple myeloma (MM). Consequently, there is increasing interest in developing strategies to target E3 ligases, de-ubiquitinases, and/or ubiquitin receptors within the ubiquitin proteasome pathway, with an aim to achieve...

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Publicat a:Oncogene
Autors principals: Crawford, Lisa J., Campbell, David C., Morgan, Jonathan J., Lawson, Michelle A., Down, Jennifer M., Chauhan, Dharminder, McAvera, Roisin M., Morris, Treen C., Hamilton, Claudia, Krishnan, Aswini, Rajalingam, Krishnaraj, Chantry, Andrew D., Irvine, Alexandra E.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7329634/
https://ncbi.nlm.nih.gov/pubmed/32523091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1345-x
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