The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in multiple myeloma

Proteasome inhibitors have provided a significant advance in the treatment of multiple myeloma (MM). Consequently, there is increasing interest in developing strategies to target E3 ligases, de-ubiquitinases, and/or ubiquitin receptors within the ubiquitin proteasome pathway, with an aim to achieve...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Crawford, Lisa J., Campbell, David C., Morgan, Jonathan J., Lawson, Michelle A., Down, Jennifer M., Chauhan, Dharminder, McAvera, Roisin M., Morris, Treen C., Hamilton, Claudia, Krishnan, Aswini, Rajalingam, Krishnaraj, Chantry, Andrew D., Irvine, Alexandra E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7329634/
https://ncbi.nlm.nih.gov/pubmed/32523091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1345-x
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