AURKA destruction is decoupled from its activity at mitotic exit but is essential to suppress interphase activity

Activity of AURKA is controlled through multiple mechanisms including phosphorylation, ubiquitin-mediated degradation and allosteric interaction with TPX2. Activity peaks at mitosis, before AURKA is degraded during and after mitotic exit in a process strictly dependent on the APC/C coactivator FZR1....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Cell Sci
Prif Awduron: Abdelbaki, Ahmed, Akman, H. Begum, Poteau, Marion, Grant, Rhys, Gavet, Olivier, Guarguaglini, Giulia, Lindon, Catherine
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Company of Biologists Ltd 2020
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7328152/
https://ncbi.nlm.nih.gov/pubmed/32393600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.243071
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