Cereblon Deletion Ameliorates Lipopolysaccharide-induced Proinflammatory Cytokines through 5′-Adenosine Monophosphate-Activated Protein Kinase/Heme Oxygenase-1 Activation in ARPE-19 Cells

Cereblon (CRBN), a negative modulator of AMP-activated protein kinase (AMPK), is highly expressed in the retina. We confirmed the expression of CRBN in ARPE-19 human retinal cells by Western blotting. We also demonstrated that CRBN knock-down (KD) could effectively downregulate IL-6 and MCP-1 protei...

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Detalhes bibliográficos
Publicado no:Immune Netw
Main Authors: Kim, Yun Kyu, Chae, Soo Chul, Yang, Hun Ji, An, Da Eun, Lee, Sion, Yeo, Myeong Gu, Lee, Kyung Jin
Formato: Artigo
Idioma:Inglês
Publicado em: The Korean Association of Immunologists 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7327155/
https://ncbi.nlm.nih.gov/pubmed/32655974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4110/in.2020.20.e26
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