An Efficient and Footprint-Free Protocol for the Transdifferentiation of Hepatocytes Into Insulin-Producing Cells With IVT mRNAs

BACKGROUND: Direct transdifferentiation of adult somatic cells into insulin-producing cells (IPCs) is a promising approach for cell-based therapies for type 1 diabetes mellitus. Liver cells are an ideal source for generating IPCs because they have regenerative ability and a developmental process sim...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Ma, Shinan, Yang, Mengjie, Zhou, Wenhui, Dai, Longjun, Ding, Yan, Guo, Xingrong, Yuan, Yahong, Tang, Junming, Li, Dongsheng, Wang, Xiaoli
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7325981/
https://ncbi.nlm.nih.gov/pubmed/32655618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2020.00575
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