A Three-Dimensional Alzheimer’s Disease Cell Culture Model Using iPSC-Derived Neurons Carrying A246E Mutation in PSEN1

Alzheimer’s disease (AD) is a chronic brain disorder characterized by progressive intellectual decline and memory and neuronal loss, caused mainly by extracellular deposition of amyloid-β (Aβ) and intracellular accumulation of hyperphosphorylated tau protein, primarily in areas implicated in memory...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Hernández-Sapiéns, Mercedes A., Reza-Zaldívar, Edwin E., Cevallos, Ricardo R., Márquez-Aguirre, Ana L., Gazarian, Karlen, Canales-Aguirre, Alejandro A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Cellular Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7325960/
https://ncbi.nlm.nih.gov/pubmed/32655369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2020.00151
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