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Infant sudden death: Mutations responsible for impaired Nav1.5 channel trafficking and function

BACKGROUND: Two genetic variants in SCN5A, encoding the Nav1.5 Na(+) channel α-subunit, were found in a 5-month-old girl who died suddenly in her sleep. The first variant is a missense mutation, resulting in an amino acid change (Q1832E), which has been described (but not characterized) in a patient...

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Publicado en:Pacing Clin Electrophysiol
Autores principales: Gando, Ivan, Morganstein, Jace, Jana, Kundan, McDonald, Thomas V., Tang, Yingying, Coetzee, William A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7325627/
https://ncbi.nlm.nih.gov/pubmed/28370132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pace.13087
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