Dual-mTOR Inhibitor Rapalink-1 Reduces Prostate Cancer Patient-Derived Xenograft Growth and Alters Tumor Heterogeneity

Bone metastasis is the leading cause of prostate cancer (PCa) mortality, frequently marking the progression to castration-resistant PCa. Dysregulation of the androgen receptor pathway is a common feature of castration-resistant PCa, frequently appearing in association with mTOR pathway deregulations...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: La Manna, Federico, De Menna, Marta, Patel, Nikhil, Karkampouna, Sofia, De Filippo, Maria Rosaria, Klima, Irena, Kloen, Peter, Beimers, Lijkele, Thalmann, George N., Pelger, Rob C. M., Jacinto, Estela, Kruithof-de Julio, Marianna
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7324765/
https://ncbi.nlm.nih.gov/pubmed/32656088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.01012
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