Phospho-HDAC6 Gathers Into Protein Aggregates in Parkinson’s Disease and Atypical Parkinsonisms

HDAC6 is a unique histone deacetylase that targets cytoplasmic non-histone proteins and has a specific ubiquitin-binding activity. Both of these activities are required for HDAC6-mediated formation of aggresomes, which contain misfolded proteins that will ultimately be degraded via autophagy. HDAC6...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Mazzetti, Samanta, De Leonardis, Mara, Gagliardi, Gloria, Calogero, Alessandra Maria, Basellini, Milo Jarno, Madaschi, Laura, Costa, Ilaria, Cacciatore, Francesca, Spinello, Sonia, Bramerio, Manuela, Cilia, Roberto, Rolando, Chiara, Giaccone, Giorgio, Pezzoli, Gianni, Cappelletti, Graziella
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7324673/
https://ncbi.nlm.nih.gov/pubmed/32655357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2020.00624
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