Cryo-EM, X-ray diffraction, and atomistic simulations reveal determinants for the formation of a supramolecular myelin-like proteolipid lattice

Myelin protein P2 is a peripheral membrane protein of the fatty acid–binding protein family that functions in the formation and maintenance of the peripheral nerve myelin sheath. Several P2 gene mutations cause human Charcot-Marie-Tooth neuropathy, but the mature myelin sheath assembly mechanism is...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Ruskamo, Salla, Krokengen, Oda C., Kowal, Julia, Nieminen, Tuomo, Lehtimäki, Mari, Raasakka, Arne, Dandey, Venkata P., Vattulainen, Ilpo, Stahlberg, Henning, Kursula, Petri
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2020
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7324508/
https://ncbi.nlm.nih.gov/pubmed/32265298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013087
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