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Free fatty acid processing diverges in human pathologic insulin resistance conditions

BACKGROUND: Postreceptor insulin resistance (IR) is associated with hyperglycemia and hepatic steatosis. However, receptor-level IR (e.g., insulin receptor pathogenic variants, INSR) causes hyperglycemia without steatosis. We examined 4 pathologic conditions of IR in humans to examine pathways contr...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Sekizkardes, Hilal, Chung, Stephanie Therese, Chacko, Shaji, Haymond, Morey W., Startzell, Megan, Walter, Mary, Walter, Peter J., Lightbourne, Marissa, Brown, Rebecca J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7324196/
https://ncbi.nlm.nih.gov/pubmed/32191645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI135431
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