NLRP3 inflammasome activation drives tau pathology

Alzheimer’s disease is characterized by the accumulation of beta-amyloid in plaques, aggregation of hyperphosphorylated tau in neurofibrillary tangles and neuroinflammation, together resulting in neurodegeneration and cognitive decline(1). The NLRP3 inflammasome assembles inside of microglia upon ac...

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Pubblicato in:Nature
Autori principali: Ising, Christina, Venegas, Carmen, Zhang, Shuangshuang, Scheiblich, Hannah, Schmidt, Susanne V., Vieira-Saecker, Ana, Schwartz, Stephanie, Albasset, Shadi, McManus, Róisín M., Tejera, Dario, Griep, Angelika, Santarelli, Francesco, Brosseron, Frederic, Opitz, Sabine, Stunden, James, Merten, Maximilian, Kayed, Rakez, Golenbock, Douglas T., Blum, David, Latz, Eicke, Buée, Luc, Heneka, Michael T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7324015/
https://ncbi.nlm.nih.gov/pubmed/31748742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1769-z
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