Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1

Aging impairs tissue repair. This is pronounced in skeletal muscle, whose regeneration by muscle stem cells (MuSCs) is robust in young adult animals but inefficient in older organisms. Despite this functional decline, old MuSCs are amenable to rejuvenation through strategies that improve the systemi...

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Bibliografske podrobnosti
izdano v:Nat Metab
Main Authors: Brett, Jamie O., Arjona, Marina, Ikeda, Mika, Quarta, Marco, de Morrée, Antoine, Egner, Ingrid M., Perandini, Luiz A., Ishak, Heather D., Goshayeshi, Armon, Benjamin, Daniel I., Both, Pieter, Rodríguez-Mateo, Cristina, Betley, Michael J., Wyss-Coray, Tony, Rando, Thomas A.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7323974/
https://ncbi.nlm.nih.gov/pubmed/32601609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-020-0190-0
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