Accurately Reflecting Uncertainty When Using Patient-Level Simulation Models to Extrapolate Clinical Trial Data

Introduction. Patient-level simulation models facilitate extrapolation of clinical trial data while allowing for heterogeneity, prior history, and nonlinearity. However, combining different types of uncertainty around within-trial and extrapolated results remains challenging. Methods. We tested 4 me...

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Detalhes bibliográficos
Publicado no:Med Decis Making
Principais autores: Dakin, Helen A., Leal, José, Briggs, Andrew, Clarke, Philip, Holman, Rury R., Gray, Alastair
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7323001/
https://ncbi.nlm.nih.gov/pubmed/32431211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0272989X20916442
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