Sequencing of RNA in single cells reveals a distinct transcriptome signature of hematopoiesis in GATA2 deficiency

Constitutional GATA2 deficiency caused by heterozygous germline GATA2 mutations has a broad spectrum of clinical phenotypes, including systemic infections, lymphedema, cytopenias, and myeloid neoplasms. Genotype–phenotype correlation is not well understood mechanistically in GATA2 deficiency. We per...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Wu, Zhijie, Gao, Shouguo, Diamond, Carrie, Kajigaya, Sachiko, Chen, Jinguo, Shi, Rongye, Palmer, Cindy, Hsu, Amy P., Calvo, Katherine R., Hickstein, Dennis D., Holland, Steven M., Young, Neal S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7322959/
https://ncbi.nlm.nih.gov/pubmed/32556286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019001352
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