The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation

BACKGROUND: Oxygen therapy, using supraphysiological concentrations of oxygen (hyperoxia), is routinely administered to patients who require respiratory support including mechanical ventilation (MV). However, prolonged exposure to hyperoxia results in acute lung injury (ALI) and accumulation of high...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Mol Med
Päätekijät: Sitapara, Ravikumar A., Gauthier, Alex G., Valdés-Ferrer, Sergio I., Lin, Mosi, Patel, Vivek, Wang, Mao, Martino, Ashley T., Perron, Jeanette C., Ashby, Charles R., Tracey, Kevin J., Pavlov, Valentin A., Mantell, Lin L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2020
Aiheet:
Short Report
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7322715/
https://ncbi.nlm.nih.gov/pubmed/32600307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10020-020-00177-z
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