The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation

BACKGROUND: Oxygen therapy, using supraphysiological concentrations of oxygen (hyperoxia), is routinely administered to patients who require respiratory support including mechanical ventilation (MV). However, prolonged exposure to hyperoxia results in acute lung injury (ALI) and accumulation of high...

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Detalhes bibliográficos
Publicado no:Mol Med
Main Authors: Sitapara, Ravikumar A., Gauthier, Alex G., Valdés-Ferrer, Sergio I., Lin, Mosi, Patel, Vivek, Wang, Mao, Martino, Ashley T., Perron, Jeanette C., Ashby, Charles R., Tracey, Kevin J., Pavlov, Valentin A., Mantell, Lin L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7322715/
https://ncbi.nlm.nih.gov/pubmed/32600307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10020-020-00177-z
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