Cerebral amyloid angiopathy-linked β-amyloid mutations promote cerebral fibrin deposits via increased binding affinity for fibrinogen

Cerebral amyloid angiopathy (CAA), where beta-amyloid (Aβ) deposits around cerebral blood vessels, is a major contributor of vascular dysfunction in Alzheimer’s disease (AD) patients. However, the molecular mechanism underlying CAA formation and CAA-induced cerebrovascular pathology is unclear. Here...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Cajamarca, Steven A., Norris, Erin H., van der Weerd, Louise, Strickland, Sidney, Ahn, Hyung Jin
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2020
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7322009/
https://ncbi.nlm.nih.gov/pubmed/32518112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921327117
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