Intratumoral CD4(+) T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer

Responses to anti-PD-1 immunotherapy occur but are infrequent in bladder cancer. The specific T cells that mediate tumor rejection are unknown. T cells from human bladder tumors and non-malignant tissue were assessed with single-cell RNA and paired T cell receptor (TCR) sequencing of 30,604 T cells...

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Published in:Cell
Main Authors: Oh, David Y., Kwek, Serena S., Raju, Siddharth S., Li, Tony, McCarthy, Elizabeth, Chow, Eric, Aran, Dvir, Ilano, Arielle, Pai, Chien-Chun Steven, Rancan, Chiara, Allaire, Kathryn, Burra, Arun, Sun, Yang, Spitzer, Matthew H., Mangul, Serghei, Porten, Sima, Meng, Maxwell V., Friedlander, Terence W., Ye, Chun Jimmie, Fong, Lawrence
Format: Artigo
Language:Inglês
Published: Cell Press 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7321885/
https://ncbi.nlm.nih.gov/pubmed/32497499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.05.017
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