Evaluation of cytochrome P450-based drug metabolism in hemorrhagic shock rats that were transfused with native and an artificial red blood cell preparation, Hemoglobin-vesicles

Hemoglobin-vesicles (Hb-V) are being developed as red blood cell (RBC) substitutes. In this study, we report on quantitative and qualitative alterations of hepatic cytochrome P450 (CYPs) and the pharmacokinetics of CYP-metabolizing drugs, with a focus on four CYP isoforms (CYP1A2, CYP2C11, CYP2E1 an...

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Publicat a:Drug Metab Pharmacokinet
Autors principals: Tokuno, Masahiro, Taguchi, Kazuaki, Sakai, Hiromi, Ohtsuki, Sumio, Yamasaki, Keishi, Otagiri, Masaki
Format: Artigo
Idioma:Inglês
Publicat: The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. 2020
Matèries:
Regular Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7320716/
https://ncbi.nlm.nih.gov/pubmed/32792327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dmpk.2020.06.004
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