The β-adrenergic receptor antagonist propranolol offsets resistance mechanisms to chemotherapeutics in diverse sarcoma subtypes: a pilot study

Standard chemotherapy for soft tissue sarcomas has shown limited efficacy. Here, we sought to evaluate whether β-adrenergic receptor (β-AR) signalling contributed to the progression of sarcomas and therapy resistance. To assess the translational potential of β-adrenergic receptors, we performed immu...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Porcelli, Letizia, Garofoli, Marianna, Di Fonte, Roberta, Fucci, Livia, Volpicella, Mariateresa, Strippoli, Sabino, Guida, Michele, Azzariti, Amalia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7320177/
https://ncbi.nlm.nih.gov/pubmed/32591592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-67342-6
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