Genetic drug target validation using Mendelian randomisation

Mendelian randomisation (MR) analysis is an important tool to elucidate the causal relevance of environmental and biological risk factors for disease. However, causal inference is undermined if genetic variants used to instrument a risk factor also influence alternative disease-pathways (horizontal...

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Publicado en:Nat Commun
Autores principales: Schmidt, Amand F., Finan, Chris, Gordillo-Marañón, Maria, Asselbergs, Folkert W., Freitag, Daniel F., Patel, Riyaz S., Tyl, Benoît, Chopade, Sandesh, Faraway, Rupert, Zwierzyna, Magdalena, Hingorani, Aroon D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7320010/
https://ncbi.nlm.nih.gov/pubmed/32591531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16969-0
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