Population Pharmacokinetics and Pharmacodynamics of Ontamalimab (SHP647), a Fully Human Monoclonal Antibody Against Mucosal Addressin Cell Adhesion Molecule‐1 (MAdCAM‐1), in Patients With Ulcerative Colitis or Crohn's Disease

Ontamalimab (SHP647) is a fully human, immunoglobulin G(2), antihuman mucosal addressin cell adhesion molecule‐1 (MAdCAM‐1) monoclonal antibody being developed for the treatment of ulcerative colitis (UC) and Crohn's disease (CD). A population pharmacokinetic/pharmacodynamic (PK/PD) analysis wa...

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Bibliographic Details
Published in:J Clin Pharmacol
Main Authors: Wang, Yi, Marier, Jean‐Francois, Lavigne, Jean, Kassir, Nastya, Martin, Patrick
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
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Non Covid Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318214/
https://ncbi.nlm.nih.gov/pubmed/32119128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1590
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