Emergence of Mycobacterium leprae Rifampin Resistance Evaluated by Whole-Genome Sequencing after 48 Years of Irregular Treatment

A case of Mycobacterium leprae rifampin resistance after irregular antileprosy treatments since 1971 is reported. Whole-genome sequencing from four longitudinal samples indicated relapse due to acquired rifampin resistance and not to reinfection with another strain. A putative compensatory mutation...

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Bibliografski detalji
Izdano u:Antimicrob Agents Chemother
Glavni autori: Avanzi, Charlotte, Maia, Raquel Cristina, Benjak, Andrej, Nery, José Augusto, Sales, Anna Maria, Miranda, Alice, Duppre, Nadia Cristina, Nogueira Brum Fontes, Amanda, Pereira da Silva, Tatiana, Olmo Pinheiro, Roberta, Neves-Manta, Fernanda, Moreira, Suelen Justo Maria, Busso, Philippe, Sarno, Euzenir Nunes, Suffys, Phillip Noel, Cole, Stewart Thomas, Moraes, Milton Ozório
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2020
Teme:
Epidemiology and Surveillance
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318023/
https://ncbi.nlm.nih.gov/pubmed/32340990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00330-20
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