Population Pharmacokinetics and Exposure-Response Relationships of Baloxavir Marboxil in Influenza Patients at High Risk of Complications

Baloxavir marboxil, a prodrug of cap-dependent endonuclease inhibitor baloxavir acid, reduces the time to improvement of influenza symptoms in patients infected with type A or B influenza virus. To characterize its pharmacokinetics, a population pharmacokinetic model for baloxavir acid was developed...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Koshimichi, Hiroki, Retout, Sylvie, Cosson, Valerie, Duval, Vincent, De Buck, Stefan, Tsuda, Yoshiyuki, Ishibashi, Toru, Wajima, Toshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318003/
https://ncbi.nlm.nih.gov/pubmed/32312784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00119-20
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