Quantum-Chemistry Based Design of Halobenzene Derivatives With Augmented Affinities for the HIV-1 Viral G(4)/C(16) Base-Pair

The HIV-1 integrase (IN) is a major target for the design of novel anti-HIV inhibitors. Among these, three inhibitors which embody a halobenzene ring derivative (HR) in their structures are presently used in clinics. High-resolution X-ray crystallography of the complexes of the IN-viral DNA transien...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Chem
Egile Nagusiak: El Darazi, Perla, El Khoury, Léa, El Hage, Krystel, Maroun, Richard G., Hobaika, Zeina, Piquemal, Jean-Philip, Gresh, Nohad
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2020
Gaiak:
Chemistry
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7317088/
https://ncbi.nlm.nih.gov/pubmed/32637391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.00440
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