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Engineering intracellular malonyl-CoA availability in microbial hosts and its impact on polyketide and fatty acid synthesis

Malonyl-CoA is an important central metabolite serving as the basic building block for the microbial synthesis of many pharmaceutically interesting polyketides, but also fatty acid–derived compounds including biofuels. Especially Saccharomyces cerevisiae, Escherichia coli, and Corynebacterium glutam...

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Detalhes bibliográficos
Publicado no:Appl Microbiol Biotechnol
Main Authors: Milke, Lars, Marienhagen, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316851/
https://ncbi.nlm.nih.gov/pubmed/32385515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00253-020-10643-7
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