Oct4-Mediated Inhibition of Lsd1 Activity Promotes the Active and Primed State of Pluripotency Enhancers

An aberrant increase in pluripotency gene (PpG) expression due to enhancer reactivation could induce stemness and enhance the tumorigenicity of cancer stem cells. Silencing of PpG enhancers (PpGe) during embryonic stem cell differentiation involves Lsd1-mediated H3K4me1 demethylation and DNA methyla...

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Publicado no:Cell Rep
Main Authors: AlAbdi, Lama, Saha, Debapriya, He, Ming, Dar, Mohd Saleem, Utturkar, Sagar M., Sudyanti, Putu Ayu, McCune, Stephen, Spears, Brice H., Breedlove, James A., Lanman, Nadia A., Gowher, Humaira
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316367/
https://ncbi.nlm.nih.gov/pubmed/32023463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.11.040
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